foreign [Music] I am Global product manager responsible for quaternary ammonium compounds at novonotis pharmatic and today I would like to discuss antimicrobial preservatives for multi-dose systems selecting a preservative system for you for your formulation can be a very complex process you would have to consider other ingredients in your formulation and the interaction with your preservative pH is of course a very important aspect and can have an influence on your preservative and how it acts against microorganisms you would have to think generally about the stability of your formulation very importantly you want your preservative to reduce microbial populations and avoid regrowth subsequently you wanted to preserve your formulation and also avoid contamination with patients pharmacopeia such as the European and the U.S from akupe have established standards to verify the efficacy of preservative systems so these pharmacopoeel guidances would require you to test your product your preservative for efficacy against a wide range of macroorganisms that includes gram positive and grab negative bacteria fungi and yeasts however not viruses this is not a requirement for preservative efficacy testing you would be including microorganisms which for example as a spiritualist Niger staphylococcus pseudomonas so these are standards in the pharmaceutical guidances however you can also add additional microorganisms if you find it relevant it can be broken Dahlia for example that you would like to test for you can find many different preservative systems available on the market today that are used very standard in Pharmaceutical formulations we're talking about alcohols acids quarter near ammonium compounds and parabens are only a few examples we partnered with the cro in the UK that are specialized in formulating nasal sprays and nasal Solutions and we asked them to compare benzoconium chloride to other standard preservatives on the market what we observed from this study is that very low concentrations of benzoconium chloride are required to obtain the desired efficacy compared to the other preservatives another aspect that is interesting here as well is that some preservatives such as parabens benzoic acid and benzyl alcohol are volatile which benzoconium chloride is not benzirconium chloride is non-volatile it's extremely stable it is effective at a very wide PH range in fact the widest PH range compared to the other preservatives and it is a very wide spectrum effective preservative which makes it an ideal preservative system for your formulations thank you very much for watching this video if you have any questions please do not hesitate to contact us